A smart case capable of monitoring blister cards having a range of formats is presented. The smart case includes a sensor system able to detect a change in the lidding film and/or content of a blister card substantially anywhere over the lateral extent of the blister card. In some embodiments, an adapter is included that enables any of a set of blister cards having different configurations (e.g., reservoir numbers, sizes, shapes, and/or inter-reservoir spacings) to be mounted in the same smart case. In some embodiments, the adapter includes walls that mitigate crosstalk between adjacent reservoirs and sensors. Sensor systems in accordance with the present disclosure provide at least one signal for each reservoir on each blister card of the set. In some embodiments, the sensor system has a density of detector elements that is at least equal to the highest density of reservoirs in any blister card of the set.