Invention Publication
- Patent Title: THYROID HORMONE RECEPTOR b SELECTIVE AGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
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Application No.: US18267298Application Date: 2021-12-10
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Publication No.: US20240059676A1Publication Date: 2024-02-22
- Inventor: Bing Zhou , Ying Leng , Yaxi Yang , Mengmeng Ning , Liuyu Hu , Lei Feng , Ju Liang
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Shanghai
- Priority: CN 2011478971.9 2020.12.15 CN 2111482622.9 2021.12.07
- International Application: PCT/CN2021/136993 2021.12.10
- Date entered country: 2023-06-14
- Main IPC: C07D403/10
- IPC: C07D403/10 ; C07D413/10 ; C07D471/04 ; A61P3/06
Abstract:
The present invention relates to a thyroid hormone receptor β selective agonist compound represented by formula I, a pharmaceutical composition and use thereof. The compound improves the selectivity to THR-α and the druggability of the compound while maintaining good THR-β agonistic activity, and shows a certain activity in in vivo pharmacological experiments.
Information query
