Invention Publication
- Patent Title: CHO INTEGRATION SITES AND USES THEREOF
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Application No.: US18461798Application Date: 2023-09-06
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Publication No.: US20240018553A1Publication Date: 2024-01-18
- Inventor: Ying Shen , Darya Burakov , Gang Chen , James P. Fandl
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Main IPC: C12N15/90
- IPC: C12N15/90 ; C12N15/85

Abstract:
Expression-enhancing nucleotide sequences for eukaryotic expressions systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Genomic integration sites providing enhanced expression and methods of use thereof are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.
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