- 专利标题： Use of Triplex CMV Vaccine in CAR T Cell Therapy
-
申请号： US18354849申请日： 2023-07-19
-
公开(公告)号： US20240016930A1公开(公告)日： 2024-01-18
- 发明人: Don J. Diamond , Xiuli Wang
- 申请人： City of Hope
- 申请人地址： US CA Duarte
- 专利权人： City of Hope
- 当前专利权人： City of Hope
- 当前专利权人地址： US CA Duarte
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K35/17 ; A61K39/285 ; A61P31/20 ; A61K39/12 ; C07K14/005 ; C07K14/00 ; C12N15/86 ; A61P35/00 ; A61K39/245 ; C07K14/725 ; C07K14/73 ; C07K14/705 ; C07K16/28 ; C12N5/0783
摘要：
A method for treating a patient comprising: (a) providing a composition comprising a population of T cells expressing both a chimeric antigen receptor (CAR) and a T cell receptor specific for a cytomegalovirus (CMV) antigen; (b) administering the composition to the patient; and (c) administering to the patient a viral vector encoding: (i) CMV pp65 and (ii) a fusion protein comprising exon 4 of CMV protein IE1 (e4) and exon 5 of CMV protein IE2 (e5) either prior to or subsequent to administering the composition comprising a population of T cells to the patient is described.
信息查询
