A system comprises a physical processor to execute a virtual machine manager to run, on a logical core, a virtual machine including a guest user application and a virtual CPU. Circuitry coupled to an external device is to receive an interrupt request from the external device for the guest user application, locate a first interrupt data structure associated with the guest user application, generate a first interrupt with the first interrupt data structure based on a first interrupt vector for the interrupt request, locate a second interrupt data structure associated with the virtual CPU, and generate a first notification interrupt for the virtual CPU with the second interrupt data structure based on a first notification vector in the first interrupt data structure. The circuitry may generate a second notification interrupt for the logical core using a second notification vector and a logical core identifier from the second interrupt data structure.