Systems and methods are provided for opportunistic spatial reuse. In various embodiments, the disclosed systems and methods provide for mechanisms for enabling and disabling spatial reuse in a wireless network as appropriate based on the deployment of the wireless network. In some embodiments, spatial reuse can be enabled and disabled based on various factors, such as channel utilization. In some embodiments, spatial reuse can be enabled and disabled as appropriate for various types of traffic in a wireless network. For example, spatial reuse can be enabled and disabled for downlink traffic (e.g., traffic from an access point to a client device), for uplink traffic (e.g., traffic from a client device to an access point), for multicast or broadcast traffic (e.g., traffic distributed to multiple recipients), or for certain modes of transmission (e.g., single user beamformed transmission, Dual Carrier Modulated transmission).