Technologies for secure data transfer of MMIO data between a processor and an accelerator. A MIMO security engine includes a first permutation cipher pipeline to defuse a count and a key into a permutation state; a first exclusive-OR (XOR) to generate ciphertext data from 64-bits of the new permutation state; and plaintext data; a concatenator to concatenate the plaintext data and additional authenticated data (AAD) to produce a concatenation result; a second XOR to generate an XOR result from the concatenation result and the latest permutation state; and a second permutation pipeline to generate an authentication tag of the XOR result and the key.