A robot for object manipulation may include sensors, a robot appendage, actuators configured to drive joints of the robot appendage, a planner, and a controller. Object path planning may include determining poses. Object trajectory optimization may include assigning a set of timestamps to the poses, optimizing a cost function based on an inverse kinematic (IK) error, a difference between an estimated required wrench and an actual wrench, and a grasp efficiency, and generating a reference object trajectory based on the optimized cost function. Grasp sequence planning may be model-based or deep reinforcement learning (DRL) policy based. The controller may implement the reference object trajectory and the grasp sequence via the robot appendage and actuators.