A driving device, an operation method thereof, and a display apparatus are disclosed. The driving device is configured to drive a display panel. The driving device divides an image frame period into a plurality of sub-frame periods. A target pixel circuit in the display panel corresponds to target pixel data comprising at least one bit. Each bit in the target pixel data corresponds to at least one corresponding sub-frame period among the sub-frame periods. Different bits in the target pixel data correspond to different sub-frame periods among the sub-frame periods. According to a current bit in the target pixel data, the driving device determines whether to light up the target pixel circuit during the at least one corresponding sub-frame period corresponding to the current bit.