发明公开
- 专利标题： ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
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申请号： US18066151申请日： 2022-12-14
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公开(公告)号： US20230321282A1公开(公告)日： 2023-10-12
- 发明人: David V. Schaffer , John G. Flannery , William A. Beltran , Leah C. Byrne , Meike Visel
- 申请人： The Regents of the University of California , The Trustees of the University of Pennsylvania
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California,The Trustees of the University of Pennsylvania
- 当前专利权人： The Regents of the University of California,The Trustees of the University of Pennsylvania
- 当前专利权人地址： US CA Oakland
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; C12N7/00 ; A61K48/00
摘要：
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
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