Described herein are methods of treating cancer comprising administering a fibroblast growth factor receptor (FGFR) inhibitor in combination with an epidermal growth factor receptor (EGFR) inhibitor, a Cyclin D1 (CCND1) inhibitor or a BRAF inhibitor to a patient in need of cancer treatment, wherein the patient harbors at least one FGFR2 genetic alteration or FGFR3 genetic alteration and at least one EGFR, CCND1 or BRAF genetic alteration, respectively. Also described herein are methods of predicting duration of progression-free survival (PFS) or overall survival (OS) in a patient, in particular a human patient, having cancer, in particular in a patient on treatment with an FGFR inhibitor, the method comprising evaluating a biological sample from the patient for the presence of at least one FGFR2 genetic alteration or FGFR3 genetic alteration and at least one EGFR, CCND1, or BRAF genetic alteration, wherein the presence of at least one FGFR2 genetic alteration or FGFR3 genetic alteration and at least one EGFR, CCND1, or BRAF genetic alteration indicates a shorter duration of PFS or a shorter duration of OS, relative to a patient, in particular a human patient, having cancer who does not harbor at least one EGFR, CCND1, or BRAF genetic alteration, respectively, or relative to a patient, in particular a human patient, having cancer who does not harbor at least one FGFR2 genetic alteration or FGFR3 genetic alteration and at least one EGFR, CCND1, or BRAF genetic alteration, respectively. Additionally, described herein are methods of improving PFS or OS in a patient with cancer relative to a patient with cancer who was not receiving treatment with an FGFR inhibitor in combination with an EGFR inhibitor, a CCND1 inhibitor or a BRAF inhibitor, said method comprising providing to said patient an FGFR inhibitor in combination with an EGFR inhibitor, a CCND1 inhibitor or a BRAF inhibitor, wherein said patient harbors at least one FGFR2 genetic alteration or FGFR3 genetic alteration and at least one EGFR, CCND1, or BRAF genetic alteration, respectively.