- 专利标题： METHOD FOR DETECTING OR TREATING TRIPLE NEGATIVE BREAST CANCER
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申请号： US18091145申请日： 2022-12-29
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公开(公告)号： US20230248721A1公开(公告)日： 2023-08-10
- 发明人: Debra Auguste , Marsha A. Moses , Peng Guo
- 申请人： Children's Medical Center Corporation
- 申请人地址： US MA Boston
- 专利权人： Children's Medical Center Corporation
- 当前专利权人： Children's Medical Center Corporation
- 当前专利权人地址： US MA Boston
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; A61K31/191 ; A61K31/4365 ; G01N33/574 ; A61K9/14 ; A61K31/429 ; C12Q1/6886 ; A61K47/54
摘要：
A method of detecting triple negative breast cancer (TNBC) is provided. Overexpression of ICAM-1 is linked to an increased risk of TNBC. A composition of matter is also provided that binds an anti-ICAM~1 antibody to a nanoparticle. The composition may be used as an imaging agent and/or a therapeutic targeting agent. A therapeutically active molecule may be bound to the composition to provide targeted therapy.
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