Provided is an automatic mattress sterilization apparatus configured to sterilize a mattress, including a frame extending in one direction and on which the mattress is placed, a sterilization part coupled to an upper portion of the frame and having an inner space through which the mattress passes, and a moving part provided in the frame and configured to move the mattress placed on the frame, and the mattress is moved from one side of the sterilization part to the other side of the sterilization part via the inner space of the sterilization part by the moving part.