发明公开
- 专利标题： STRUCTURALLY-STABILIZED GLUCAGON-LIKE PEPTIDE 1 PEPTIDES AND USES THEREOF
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申请号： US17786157申请日： 2020-12-18
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公开(公告)号： US20230183309A1公开(公告)日： 2023-06-15
- 发明人: Loren D. Walensky , Gregory H. Bird
- 申请人： Dana-Farber Cancer Institute, Inc.
- 申请人地址： US MA Boston
- 专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址： US MA Boston
- 国际申请： PCT/US2020/066094 2020.12.18
- 进入国家日期： 2022-06-16
- 主分类号： C07K14/605
- IPC分类号： C07K14/605 ; A61P3/10 ; A61K9/00
摘要：
This disclosure features structurally-stabilized peptides that target glucagon-like peptide 1 receptor (GLP-1R), compositions comprising same, and methods for using such peptides in the treatment of diabetes, hyperglycemia, cardiovascular disease, obesity, Alzheimer’s disease, Huntington’s disease, and other conditions that can benefit from increased GLP-1 agonist activity and in increasing cAMP levels
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