Invention Publication
- Patent Title: INHIBITORS OF LRRK2 KINASE
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Application No.: US18065259Application Date: 2022-12-13
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Publication No.: US20230183217A1Publication Date: 2023-06-15
- Inventor: David James Bearss , John Sai Keong Kauwe, III , Alexis Henri Abel Mollard
- Applicant: Halia Therapeutics, Inc.
- Applicant Address: US UT Salt Lake City
- Assignee: Halia Therapeutics, Inc.
- Current Assignee: Halia Therapeutics, Inc.
- Current Assignee Address: US UT Salt Lake City
- The original application number of the division: US17702600 2022.03.23
- Main IPC: C07D403/14
- IPC: C07D403/14 ; C07D239/47 ; C07D401/14 ; C07D403/12 ; C07D405/14 ; C07D413/12 ; C07D413/14 ; C07D491/107 ; C07D498/08

Abstract:
Compounds having activity as inhibitors of LRRK2 kinase are provided. The compounds have Structure (I):
or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein A, B, R1a, R1b, R2, and L are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of LRRK2 kinase are also provided.
or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein A, B, R1a, R1b, R2, and L are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of LRRK2 kinase are also provided.
Public/Granted literature
- US11866423B2 Inhibitors of LRRK2 kinase Public/Granted day:2024-01-09
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