Provided are a touch substrate, a display panel, and a touch display device. The touch substrate, including: a base substrate; a conductive layer on the base substrate, the conductive layer being a single-layer structure, and the conductive layer including a plurality of touch electrodes and a plurality of leads electrically connected with the plurality of touch electrodes; where: a first grid-like structure is formed between adjacent leads, and a first disconnection line is arranged between the adjacent leads in the first grid-like structure; the touch electrodes have a second grid-like structure, and the second grid-like structure includes a plurality of breakpoints; and a connection line between the plurality of breakpoints has a substantially same shape as the first disconnection line.