A system and method for dynamically optimizing content delivery in a wireless communication network. The method comprises receiving, at a transceiver [208A], a request for delivery of a content from at least one user device [202]. A manifest module [208B] determines one or more first parameters for the at least one user device [202] and compares one or more parameters of the at least one user device [202] with one or more second parameters of the at least one cohort. The manifest module [208B] dynamically identifies (or generates) a virtual manifest associated with the at least one cohort (or the at least one user device [202]) based on the comparison. A segmenter module [208C] automatically extracts a stream of data associated with the virtual manifest. The transceiver [208A] delivers the content to the at least one user device [202] based on the extracted stream of data.