- 专利标题： TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF
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申请号： US17596491申请日： 2020-06-12
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公开(公告)号： US20220306603A1公开(公告)日： 2022-09-29
- 发明人: Frederick WEST , Jack TUSZYNSKI , Michael WEINFELD , Khaled Hassan BARAKAT , Ahmed H. ELMENOUFY , Francesco GENTILE , Feridoun KARIMI-BUSHERI , Claudia WEILBEER
- 申请人： The Governors of the University of Alberta
- 申请人地址： CA Edmonton
- 专利权人： The Governors of the University of Alberta
- 当前专利权人： The Governors of the University of Alberta
- 当前专利权人地址： CA Edmonton
- 国际申请： PCT/CA2020/050823 WO 20200612
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D471/04 ; C07D413/14
摘要：
The current application relates to pyronaridine or 6-chloro-2-methoxyacridine analogs having binding affinity for the ERCC1-XPF hetero-dimerization interface. The compounds can be used for targeting DNA repair in tumor cells via ER-CC1-XPF inhibition, therefore improving the therapeutic benefit of irradiation or other cancer treatment, or reducing the dosage and adverse effects associated with such treatment.
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