Invention Application
- Patent Title: 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF
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Application No.: US17405506Application Date: 2021-08-18
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Publication No.: US20220267286A2Publication Date: 2022-08-25
- Inventor: Rui Manuel Pontes Meireles Ferreira de Brito , Carlos José Vieira Simões , Teresa Margarida Vasconcelos Dias de Pinho e Melo , Bruno Lourenço da Silva Victor , Zaida Catarina Lourenço de Almeida , Ana Lúcia Cabral Cardoso Lopes , Bruno Filipe Oliveira Nascimento
- Applicant: Rui Manuel Pontes Meireles Ferreira de Brito , Carlos José Vieira Simões , Teresa Margarida Vasconcelos Dias de Pinho e Melo , Bruno Lourenço da Silva Victor , Zaida Catarina Lourenço de Almeida , Ana Lúcia Cabral Cardoso Lopes , Bruno Filipe Oliveira Nascimento
- Applicant Address: PT Coimbra; PT Cantanhede; PT Coimbra; PT Cantanhede; PT Coimbra; PT Coimbra; PT Coimbra
- Assignee: Rui Manuel Pontes Meireles Ferreira de Brito,Carlos José Vieira Simões,Teresa Margarida Vasconcelos Dias de Pinho e Melo,Bruno Lourenço da Silva Victor,Zaida Catarina Lourenço de Almeida,Ana Lúcia Cabral Cardoso Lopes,Bruno Filipe Oliveira Nascimento
- Current Assignee: Rui Manuel Pontes Meireles Ferreira de Brito,Carlos José Vieira Simões,Teresa Margarida Vasconcelos Dias de Pinho e Melo,Bruno Lourenço da Silva Victor,Zaida Catarina Lourenço de Almeida,Ana Lúcia Cabral Cardoso Lopes,Bruno Filipe Oliveira Nascimento
- Current Assignee Address: PT Coimbra; PT Cantanhede; PT Coimbra; PT Cantanhede; PT Coimbra; PT Coimbra; PT Coimbra
- Main IPC: C07D277/36
- IPC: C07D277/36 ; C07D277/34 ; A61K9/00 ; A61K31/426 ; A61K45/06
Abstract:
Compounds are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).
Public/Granted literature
- US11584727B2 2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof Public/Granted day:2023-02-21
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