Tamper-evident bag is disclosed. In one embodiment, the tamper-evident bag may include a bag body. The bag body may include a first side and a second side and a first collapsible side and a second collapsible side transverse to the first and second sides with a bag bottom and a bag opening at a top of the bag body. The tamper-evident bag may further include, a loop-style handle secured to the first side of the bag body and a loop-style handle secured to the second side of the bag body with the loop-style handles arranged with respect to the bag opening; and a sealable flap extending up from the first bag side at an edge of the bag opening of the bag body. The sealable flap may include a perforated fold along the sealable flap and slots in a portion of the sealable flap that extends above an edge of the bag body at the bag opening of the bag body, the slots may be positioned on the sealable flap with respect to the handles to provide clearance for the handles when the sealable flap is folded along the perforated fold to be secured to the second side of the bag body.