A system and method for an artificial tendon or muscle driven prosthesis that may include an articulating prosthesis with a set of actuation points; an artificial tendon system, the artificial tendon system being integrated with the articulating prosthesis and comprising an external tendon actuation interface coupled relative to at least one actuation point of the set of actuation points, and the artificial tendon system further comprising integration with a musculoskeletal-integrated internal artificial tendon; and an osseointegration abutment through which the artificial tendon system couples the external tendon actuation interface to the musculoskeletal-integrated internal artificial tendon integration and can implement an infection mitigation system.