- 专利标题： COMPOSITIONS AND METHODS FOR TREATING CYTOKINE RELEASE SYNDROME
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申请号： US17587501申请日： 2022-01-28
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公开(公告)号： US20220233690A1公开(公告)日： 2022-07-28
- 发明人: Kara OLSON , Olga Sineshchekova , Eric Smith , Chiayang Lin
- 申请人： Regeneron Pharmaceuticals, Inc.
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K38/17 ; A61K35/17 ; A61P35/00 ; A61P37/06
摘要：
The present invention provides compositions and methods for treating cancer and inhibiting cytokine release syndrome (CRS). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a CD40 antagonist or a CAR-T cell expressing a CD40 antagonist in combination with a therapeutically effective amount of a CD3 multispecific antigen binding molecule.
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