- 专利标题: SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS
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申请号: US17431091申请日: 2020-02-14
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公开(公告)号: US20220213026A1公开(公告)日: 2022-07-07
- 发明人: Dean A. Wacker , Susheel Jethanand Nara , Srinivas Cheruku , Kandhasamy Sarkunam , Firoz Ali Jaipuri , Soodamani Thangavel , Rishikesh Narayan , Subba Reddy Bandreddy , Srinivas Jogi , Pavan Kalyan Kathi
- 申请人: BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址: US NJ Princeton
- 专利权人: BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人: BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址: US NJ Princeton
- 国际申请: PCT/US2020/018217 WO 20200214
- 主分类号: C07C233/61
- IPC分类号: C07C233/61 ; C07D295/04 ; C07D207/06 ; C07D205/04 ; C07D309/04 ; C07D405/14 ; C07D271/06 ; C07D277/64 ; C07D413/04 ; C07D405/04
摘要:
Disclosed are compounds of Formula (I) or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, wherein Q is a 5-membered heterocyclyl or 5-membered heteroaryl having 1 to 4 heteroatoms independently selected from N, O, and S, substituted with zero to 4 R1; and A, X1, X2, X3, X4, Z1, Z2, R1, R2, R3a, R3b, a, b, and d are defined herein. Also disclosed are methods of using these compounds to modulate the activity of farnesoid X receptor (FXR); pharmaceutical compositions comprising these compounds; and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
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