- 专利标题: NEW DRY POWDER COMPOSITION FOR PERORAL ADMINISTRATION
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申请号: US17696984申请日: 2022-03-17
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公开(公告)号: US20220202726A1公开(公告)日: 2022-06-30
- 发明人: Ola CAMBER , Arnout EVERAERT , Stefan GRUDÉN
- 申请人: VICORE PHARMA AB
- 申请人地址: SE Stockholm
- 专利权人: VICORE PHARMA AB
- 当前专利权人: VICORE PHARMA AB
- 当前专利权人地址: SE Stockholm
- 优先权: GB2006079.4 20200424
- 主分类号: A61K9/48
- IPC分类号: A61K9/48 ; C07D403/08 ; A61K9/00
摘要:
There is provided a pharmaceutical dosage form that is suitable for peroral administration to the gastrointestinal tract, which dosage form comprises a pharmaceutical composition in the form of a particulate mixture comprising solid particles of N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically-acceptable salt thereof, admixed with a blend of carrier particles with weight- and/or a volume-based mean diameter, and/or a structural/particle density, that is/are similar to the weight- and/or volume-based mean diameter, and/or the structural/particle density, of the solid particles of C21, and a glidant, which composition is contained within a capsule that is suitable for such peroral administration. Preferred carrier particles have a weight- and/or a volume-based mean diameter that is less than about 100 μm. Preferred carrier particle materials include mannitol. Preferred glidants comprise colloidal silica. Such dosage forms find utility in the treatment of lung diseases, such as idiopathic pulmonary fibrosis, sarcoidosis and respiratory virus-induced tissue damage.
公开/授权文献
- US11844868B2 Dry powder composition for peroral administration 公开/授权日:2023-12-19
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