- 专利标题: REPLICATION-DEFICIENT MODIFIED VACCINIA ANKARA (MVA) EXPRESSING MARBURG VIRUS GLYCOPROTEIN (GP) AND MATRIX PROTEIN (VP40)
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申请号: US17584231申请日: 2022-01-25
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公开(公告)号: US20220152190A1公开(公告)日: 2022-05-19
- 发明人: Harriett Robinson , Arban Domi , Michael Hellerstein
- 申请人: GeoVax, Inc.
- 申请人地址: US GA Smyma
- 专利权人: GeoVax, Inc.
- 当前专利权人: GeoVax, Inc.
- 当前专利权人地址: US GA Smyma
- 主分类号: A61K39/12
- IPC分类号: A61K39/12 ; C12N15/863 ; C12N15/86
摘要:
The compositions and methods are described for generating an immune response to a hemorrhagic fever virus such as ebolavirus, Marburgvirus, or arenavirus. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a member of genus Ebolavirus (such as a member of species Zaire ebolavirus), a member of genus Marburgvirus (such as a member of species Marburg marburgvirus), or a member of genus Arenavirus (such as a member of species Lassa virus) in the subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat an infection caused by ebolavirus, Marburgvirus, or arenavirus.
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