Embodiments of the present disclosure provide a logistics information processing method and apparatus, and a device. The method includes: a blockchain node receives a locking request sent by a handheld terminal, and the locking request includes an identifier of an electronic lock on a logistics box and a waybill number of an item in the logistics box; the blockchain node acquires an unlocking key of the electronic lock corresponding to the waybill number according to the locking request, and the unlocking key is confirmed by a receiving terminal corresponding to the item; the blockchain node generates a locking instruction according to the unlocking key and the waybill number, and sends the locking instruction to the electronic lock, where the locking instruction is used to instruct the electronic lock to lock, and store the unlocking key and the waybill number. Logistics security of the item is improved.