Invention Application
- Patent Title: SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS
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Application No.: US17430903Application Date: 2020-02-14
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Publication No.: US20220081430A1Publication Date: 2022-03-17
- Inventor: Dean A. Wacker , Susheel Jethanand Nara , Srinivas Cheruku , Kandhasamy Sarkunam , Firoz Ali Jaipuri , Soodamani Thangavel , Rishikesh Narayan , Srinivas Jogi , Pavan Kalyan Kathi
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- International Application: PCT/US2020/018211 WO 20200214
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D401/12 ; C07D271/06 ; C07D213/26 ; C07D417/12

Abstract:
Disclosed are compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, when Q is: (i) halo, cyano, hydroxyl, NRxRx, C(O)OH, C(O)NH2, C1-6 alkyl substiuted with zero to 6 R1a, or P(O)R1cR1c, or (ii) L R1; and A, X1, X2, X3, X4, Z1, Z2, R1, R1a, R1c, R2, R3a, R3b, Rx, L, a, b, and d are defined herein. Also disclosed are methods of using these compounds to modulate the activity of farnesoid X receptor (FXR); pharmaceutical compositions comprising these compounds; and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
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