- 专利标题： ANTI-LAP ANTIBODY VARIANTS AND USES THEREOF
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申请号： US17465247申请日： 2021-09-02
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公开(公告)号： US20220017612A1公开(公告)日： 2022-01-20
- 发明人: Randall Burton , Jessie M. English , Barbara S. Fox , Stavros Kopsiaftis , Yacob Gomez Llorente , Renee Moore , Patricia Rao , Giovanna Scapin , Kenneth J. Simon , Haihong Zhou
- 申请人： Tilos Therapeutics, Inc. , Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway; US NJ Rahway
- 专利权人： Tilos Therapeutics, Inc.,Merck Sharp & Dohme Corp.
- 当前专利权人： Tilos Therapeutics, Inc.,Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway; US NJ Rahway
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; A61P35/04 ; A61P35/00 ; G01N33/574 ; G01N33/68
摘要：
Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGFβ1 on cells but not to LAP-TGFβ1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
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