In accordance with embodiments, there are provided mechanisms and methods for facilitating secure communication of data during transactions across multiple transaction entities in database systems according to one embodiment. In one embodiment and by way of example, a method includes receiving a request to facilitate a financial transaction, wherein the request is received from an external computing device and includes sensitive data and one or more transient keys associated with a user, and selecting a gateway from multiple gateways to facilitate performance of the financial transaction, where the gateway is selected based on participation in securing of the sensitive data. The method may further include replacing, based on the one or more transient keys, the sensitive data with substitute data that is unique to the user, and communicating the substitute data to a gateway adapter to generate a file for the gateway, where the substitute data is communicated in lieu of the sensitive data, and converting the substitute data into the sensitive data.