Provided herein are, inter alia, recombinant cytokine receptor binding proteins including a cytokine domain bound to an occlusion domain and a receptor domain through a first and second linker, respectively. The occlusion domain hinders the cytokine domain from binding to its cognate receptor. The chemical linkers (e.g., first and/or second chemical linker) included in the recombinant proteins provided herein may be cleavable and thereby conveying disease site specificity to the compositions provided herein. In the presence of a tumor-specific protease the first and/or second chemical linker is cleaved and the cytokine domain is released from the occlusion domain and the receptor domain and is capable of binding its cognate receptor. The recombinant proteins provided herein may therefore have multi-specific binding capabilities useful for therapeutic and diagnostic purposes.