The present invention discloses a five cylinder plunger pump with an integral power end structure. In the power end assembly of the five cylinder plunger pump, the crankcase and the crosshead case adopt an integral welding structure, so that the power end assembly has a higher structural strength and a better support stability to reduce vibration of the whole pump. The cylinder spacing is 13-14 inches, increasing the bearing area of the connecting rod, the crosshead and the bearing bushes, and ensuring the high power output of the five cylinder plunger pump. The high power five cylinder plunger pump can effectively solve the problems of narrow area in shale gas fracturing wellsite and the need for multiple fracturing equipment, thus reducing the use of equipment and facilitating the arrangement of the wellsite. The long stroke design of 11 inches is beneficial to realize the operation requirement of large displacement and enhance the operation efficiency. The multi-point support design of the crankcase, the crosshead case and the hydraulic end assembly can enhance the support strength of the five cylinder plunger pump and reduce the vibration, thus better ensuring high load operation and more smoothly running.