A needle-free injector includes a housing, a cartridge positioned within the housing, and a plunger slidably coupled to and disposed within the chamber, a motor operatively coupled to the plunger, the motor operable to actuate the plunger in the chamber, and a controller operatively coupled to the motor. Methods of delivering an injectate using the needle-free injectors are provided. Methods of facilitating needle-free injection of a fluid using the needle-free injectors are also provided.