- 专利标题： METHODS OF TREATING BREAST CANCER WITH TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS
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申请号： US17001519申请日： 2020-08-24
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公开(公告)号： US20210060008A1公开(公告)日： 2021-03-04
- 发明人: Xin CHEN , Andrew P. CREW , John FLANAGAN , Sheryl Maxine GOUGH , Royal J. HASKELL, III , Marcia Dougan MOORE , Yimin QIAN , Ian Charles Anthony TAYLOR , Jing WANG
- 申请人： Arvinas Operations, Inc.
- 申请人地址： US CT New Haven
- 专利权人： Arvinas Operations, Inc.
- 当前专利权人： Arvinas Operations, Inc.
- 当前专利权人地址： US CT New Haven
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K47/38 ; A61K47/26 ; A61K47/02 ; A61K47/22 ; A61K31/519 ; A61P35/00
摘要：
The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2− breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.
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