A portable anomaly drug detection device is disclosed. The device includes at least one light source, a detector to scan or process the subject drug, and a control circuit having a controller. The at least one light source, the camera, and the control circuit are disposed within an enclosure. The controller is configured to process and analyze drug images captured by the camera when the light source emits light, and determines whether a drug is counterfeit upon detection of an anomaly within the captured images relative to a trained counterfeit detecting machine-learning model.