An enterprise inventory management system, and methods of use thereof, including a global inventory database subsystem for cataloging a plurality of inventory items, each of the items identified by at least a unique identification code; and, a radio frequency identification (RFID) interrogator subsystem, the RFID interrogator subsystem operative to read radio RFID tags associated with each of the plurality of inventory items, wherein each of the RFID tags is programmed with at least a unique identification code for its associated item. The system provides functionality for improved single item identification/location, verification of shipping and receiving of inventory items, and inventory operations utilizing single or multiple RFID interrogators.