- 专利标题： HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
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申请号： US16736078申请日： 2020-01-07
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公开(公告)号： US20200345735A1公开(公告)日： 2020-11-05
- 发明人: Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Leivers , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
- 申请人： Array BioPharma Inc. , Genentech, Inc.
- 申请人地址： US CO Boulder US CA South San Francisco
- 专利权人： Array BioPharma Inc.,Genentech, Inc.
- 当前专利权人： Array BioPharma Inc.,Genentech, Inc.
- 当前专利权人地址： US CO Boulder US CA South San Francisco
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; C07D409/12 ; C07D409/14 ; C07D239/70 ; C07D413/12 ; C07D407/12
摘要：
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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