Systems and methods for monitoring a positioning and vital signs of a subject are disclosed. A method includes receiving, by a processing device of a monitoring device, LWIR image data from a first imaging component of the monitoring device and NIR image data from a second imaging component of the monitoring device, determining one or more boundaries of the patient support apparatus from the NIR image data, constructing one or more virtual boundaries that correspond to the boundaries of the patient support apparatus, determining a location of the subject with respect to the virtual boundaries from at least one of the LWIR image data and the NIR image data, determining a facial temperature and a heart rate of the subject from the LWIR image data, and determining a respiration rate of the subject from at least one of the LWIR image data and the NIR image data.