Invention Application
- Patent Title: STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF
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Application No.: US16609612Application Date: 2018-05-01
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Publication No.: US20200147213A1Publication Date: 2020-05-14
- Inventor: Manoj K. Sharma , Wendy Benjamin , Sarita Mittal , Ashwin Basarkar , Chakravarthy Nachu Narasimhan , Ramesh S. Kashi , Mohammed Shameem , Soumendu Bhattacharya , William P. Forrest, JR. , Yogita Krishnamachari
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- International Application: PCT/US2018/030459 WO 20180501
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K47/26 ; A61K47/34 ; A61K47/18 ; A61K9/19

Abstract:
The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations of the invention comprise between 5-200 mg/mL anti-PD-1 antibody, or antigen binding fragment thereof. The invention further provides methods for treating various cancers with stable formulations of the invention. In some embodiments of the methods of the invention, the formulations are administered to a subject by intravenous or subcutaneous administration.
Public/Granted literature
- US11633476B2 Stable formulations of programmed death receptor 1 (PD-1) antibodies and methods of use thereof Public/Granted day:2023-04-25
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