- 专利标题： MIC-1 COMPOUNDS AND USES THEREOF
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申请号： US16614454申请日： 2018-05-23
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公开(公告)号： US20200079829A1公开(公告)日： 2020-03-12
- 发明人: Xiang Gao , Xujia Zhang , Hongtao Guan , Henning Thoegersen , Kristian Sass-Oerum , Lars Fogh Iversen , Per Noergaard , Sebastian Beck Joergensen , Kristian Tage Hansen , Yi Wang , Kilian Waldemar Conde Frieboes , Birgit Wieczorek
- 申请人： Novo Nordisk A/S
- 优先权： CNPCT/CN2017/085576 20170523; CNPCT/CN2017/113335 20171128
- 国际申请： PCT/EP2018/063476 WO 20180523
- 主分类号： C07K14/495
- IPC分类号： C07K14/495
摘要：
The invention relates to MIC-1 compounds. More specifically it relates to compounds comprising a MIC-1 polypeptide with an N-terminal amino acid extension and a protractor wherein the amino acid extension comprises 3 to 36 amino acid residues and where the MIC-1 polypeptide and the N-terminal amino acid extension together have a calculated pI lower than 6.5. The compounds of the invention have MIC-1 activity. The invention also relates to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable excipients, as well as the medical use of the compounds.
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