Systems and methods are provided for selecting from among polygenic models that predict characteristics of individuals. One embodiment is a genetic prediction server that includes a memory that stores polygenic models which predict characteristics of individuals based on genetic variants of the individuals, including a set of polygenic models for a characteristic that each perform a different analysis of genetic variants when making a prediction. The server also includes a controller that receives an indication of genetic variants of an individual, determines that the individual belongs to a demographic, and selects, based on the demographic, a polygenic model from the set to predict the characteristic for the individual.