- 专利标题: COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS
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申请号: US16297190申请日: 2019-03-08
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公开(公告)号: US20190292135A1公开(公告)日: 2019-09-26
- 发明人: Brent R. Stockwell , Rachid Skouta , Scott Dixon
- 申请人: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 主分类号: C07C229/56
- IPC分类号: C07C229/56 ; C07C229/60 ; C07D401/12 ; C07D239/26 ; C07D213/38 ; A61K45/06 ; A61K31/196 ; A61K31/505 ; C07C255/58 ; A61K31/245 ; C07C271/24
摘要:
The present invention provides, inter alia, a compound having the structure of Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
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