A system for user-initiated analysis of changes in symptoms of a patient is described. The system includes a storage device for storing data captured of a patient performing an action in response to a stimulus presented to the patient. The stimulus presented to the patient includes one or more instructions provided to the patient in accordance with monitoring of medication administration of the patient. The action performed in response to the stimulus presented to the patient includes the action of the patient performing a requested step indicative of proper medication administration and is indicative of a change in one or more symptoms associated with a disease and the overall progression of the disease, the storage device further storing one or more item selected from the group of: demographic information of the patient, disease progression information of the patient, and one or more medication characteristics of the medication subject to the medication administration monitoring process. The system further includes a user input module for receiving input from a user indicative of a request for information, and a processor for determining, in response to the user input request for information, and in accordance with the captured data of the patient performing the action in response to the stimulus, a correlation between two or more of the following: one or more of the determined stored reactions, the demographic information of the patient, the disease progression information of the patient, and the one or more medication characteristics of the medication, the correlation being used to determine efficacy of the medication; and an output module for returning to the user information comprising the determined correlation.