发明申请
- 专利标题： CD31SHED AGONISTS FOR USE IN THE PREVENTION AND/OR TREATMENT OF REPERFUSION INJURY
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申请号： US16087223申请日： 2017-03-21
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公开(公告)号： US20190105369A1公开(公告)日： 2019-04-11
- 发明人: Giuseppina CALIGIURI , Jean-Baptiste MICHEL , Antonino NICOLETTI
- 申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM) , UNIVERSITÉ PARIS DIDEROT - PARIS 7 , UNIVERSITE PARIS 13 - PARIS NORD
- 申请人地址： FR Paris FR Paris FR Villetaneuse
- 专利权人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM),UNIVERSITÉ PARIS DIDEROT - PARIS 7,UNIVERSITE PARIS 13 - PARIS NORD
- 当前专利权人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM),UNIVERSITÉ PARIS DIDEROT - PARIS 7,UNIVERSITE PARIS 13 - PARIS NORD
- 当前专利权人地址： FR Paris FR Paris FR Villetaneuse
- 优先权： EP16305311.9 20160321
- 国际申请： PCT/EP2017/056733 WO 20170321
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61P9/10
摘要：
Disclosed are CD31shed agonists for use in the prevention and/or treatment of reperfusion injury. These CD31shed agonists are peptides or peptidomimetics thereof that are able to restore CD31 signaling in cells bearing a truncated form of CD31 called CD31shed. The CD31shed agonists particularly protect from organ damages caused by reperfusion used to treat ischemia.
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