[Object] To reduce a risk that a tone of a specific color component of a subject to be observed in medical operation is defective.[Solution] There is provided a medical image processing device including: a signal acquisition unit configured to acquire a first specific component image signal with a first exposure for a specific color component, a second specific component image signal with a second exposure different from the first exposure for the specific color component, and two non-specific component image signals corresponding to two color components different from the specific color component; a combination unit configured to generate a specific component combination image signal by combining the first specific component image signal and the second specific component image signal by using a weight based on an intensity of the specific color component; and a color image generation unit configured to generate a color image signal on a basis of the specific component combination image signal generated by the combination unit and the two non-specific component image signals.