- 专利标题: FACTOR XIA MACROCYCLE INHIBITORS BEARING A NON-AROMATIC P2' GROUP
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申请号: US15747867申请日: 2016-07-28
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公开(公告)号: US20190010154A1公开(公告)日: 2019-01-10
- 发明人: Yeheng Zhu , Andrew K. Dilger , William R. Ewing , Michael J. Orwat , Donald J.P. Pinto
- 申请人: BRISTOL-MYERS SQUIBB COMPANY
- 国际申请: PCT/US2016/044363 WO 20160728
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61P7/02
摘要:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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