发明申请
- 专利标题: Novel Ferroportin Inhibitors
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申请号: US15769148申请日: 2016-10-21
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公开(公告)号: US20180319783A1公开(公告)日: 2018-11-08
- 发明人: Franz Dürrenberger , Michael Burgert , Susanna Burckhardt , Wilm Buhr , Aris Kalogerakis , Stefan Reim , Vania Manolova , Susan Boyce , Christopher John Yarnold , Paula Pena , Jon Shepherd , Cristina Lecci , Richard Jarjes-Pike , John Scott
- 申请人: Vifor (International) AG
- 优先权: EP15191176.5 20151023; EP15191179.9 20151023
- 国际申请: PCT/EP2016/075306 WO 20161021
- 主分类号: C07D413/14
- IPC分类号: C07D413/14 ; C07D417/14 ; C07D417/12 ; C07D413/04 ; C07D401/14 ; C07D403/14 ; C07D471/04 ; C07D487/04 ; A61P25/16 ; A61P25/28 ; A61P3/12 ; A61P7/06
摘要:
The invention relates to novel compounds of the general formula (A-I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula (AA) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
公开/授权文献
- US10364239B2 Ferroportin inhibitors 公开/授权日:2019-07-30
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