- 专利标题： METHODS AND COMPOSITIONS FOR MODIFYING MACROPHAGE POLARIZATION INTO PRO-INFLAMMATORY CELLS TO TREAT CANCER
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申请号： US15769689申请日： 2016-10-21
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公开(公告)号： US20180312600A1公开(公告)日： 2018-11-01
- 发明人: Nicolas Poirier , Bernard Vanhove , Vanessa Gauttier
- 申请人： OSE IMMUNOTHERAPEUTICS
- 优先权： EP15190918.1 20151021
- 国际申请： PCT/EP2016/075466 WO 20161021
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C12N5/0786 ; A61P35/00
摘要：
The present disclosure concerns the use of an anti-SIRPa compound able to inhibit the polarization of anti-inflammatory M2-type macrophages and/or favors pro-inflammatory M1-type macrophages. In a preferred embodiment, such compound is used to treat cancer. Interestingly, this disclosure allows to treat cancer through an indirect pathway involving the immune system.
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