发明申请
- 专利标题： Stabilized Modified Release Vitamin D Formulation and Method of Administering Same
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申请号： US15990352申请日： 2018-05-25
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公开(公告)号： US20180271884A1公开(公告)日： 2018-09-27
- 发明人: Jay A. White , Samir P. Tabash , Sammy A. Agudoawu , Joel Z. Melnick
- 申请人： OPKO IRELAND GLOBAL HOLDINGS, LTD.
- 主分类号： A61K31/593
- IPC分类号： A61K31/593 ; A61K9/48 ; A61K9/28 ; A61K9/20 ; A61K47/38 ; A61K47/44 ; A61K31/592
摘要：
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 and a cellulosic compound. The stabilized formulations exhibit a stable dissolution profile following exposure to storage conditions and demonstrate improved pharmacokinetic parameters compared to unstabilized formulations.
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