Embodiments described herein are directed to methods of manufacturing a multi-leaf membrane module for filtering product fluid flow (e.g., food products or wastewater) and such multi-leaf membrane modules. In an embodiment, a multi-leaf membrane module is disclosed. The multi-leaf membrane module includes a permeate fluid flow tube defining a permeate fluid flow channel for permeate, and a membrane sheet spirally wound about the permeate fluid flow tube. The membrane sheet includes two or more leaves. Each of the two or more leaves includes a feed spacer including at least one opening formed therein that at least partially defines a feed channel for product fluid flow therethrough and a permeate structure defining a permeate fluid flow channel. The permeate structure of each of the two or more leaves includes at least one membrane and at least one porous permeate spacer.