Invention Application
- Patent Title: METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
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Application No.: US15882228Application Date: 2018-01-29
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Publication No.: US20180236043A1Publication Date: 2018-08-23
- Inventor: Kamel KHALILI , Wenhui HU
- Applicant: Temple University of the Commonwealth System of Higher Education
- Applicant Address: US PA Philadelphia
- Assignee: Temple University of the Commonwealth System of Higher Education
- Current Assignee: Temple University of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Philadelphia
- Main IPC: A61K38/46
- IPC: A61K38/46 ; C12N7/00 ; A61K9/00 ; A61K35/12 ; A61K45/06 ; A61K48/00 ; C12N9/22 ; C12N15/11
Abstract:
A method of treating a subject having or at risk for having a virus infection, by administering to the subject a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated endonuclease and at least two guide RNAs, wherein the guide RNAs are complementary to two target sequences spanning from the 5′- to 3′-LTRs of the sequence in the virus. A method of treating a subject having or at risk for having a virus infection, by administering to the subject a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated endonuclease and at least two guide RNAs, wherein the guide RNAs are complementary to two target sequences spanning from the 5′- to 3′-LTRs of the sequence in the virus, and causing neither genotoxicity nor off-target editing to the host.
Information query
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